抗菌肽 B結構式
|
常用名 | 抗菌肽 B | 英文名 | Cecropin B |
|---|---|---|---|---|
| CAS號 | 80451-05-4 | 分子量 | 3834.67 | |
| 密度 | N/A | 沸點 | N/A | |
| 分子式 | C176H302N52O41S | 熔點 | N/A | |
| MSDS | 美版 | 閃點 | N/A |
抗菌肽 B用途Cecropin B 有著高水平的抗菌活性,且是一種有價值的肽類抗菌素。 |
| 中文名 | 抗菌肽 B |
|---|---|
| 英文名 | Cecropin B |
| 英文別名 | 更多 |
| 描述 | Cecropin B 有著高水平的抗菌活性,且是一種有價值的肽類抗菌素。 |
|---|---|
| 相關類別 | |
| 體外研究 | Cecropin B-誘導NF-κB活化通過破壞PXR /類視黃醇X受體α(RXR-α)復合物與DNA序列的結合在抑制CYP3A29中起關鍵作用。 Cecropin B通過與TLRs 2和4相互作用激活豬肝細胞,TLRs 2和4調節NF-κB介導的信號通路[1]。 |
| 體內研究 | 傷口濕潤,C組滲出較多,而其他組則干燥,無明顯滲出。每組中大多數小鼠的體溫升高,但每組中白細胞的數量在手術后降低。 A組肌肉細菌數量明顯低于M組和C組。 C組4個PID后存活小鼠的數量明顯少于A組和M組(P <0.05)[2]。 |
| 動物實驗 | 小鼠[1]將30只ICR小鼠納入研究，并通過切除1cm×1cm面積的背皮全層來復制銅綠假單胞菌感染模型。然后將它們隨機分為C組（對照組，n = 10，在傷后3小時（PIH）用等壓生理鹽水濕敷），M（在3 PIH下用100g / L的磺胺類藥物進行親水性壓縮），A（濕敷）在3個PIH）組中的1 000 mg / L天蠶素B。在損傷前和傷后4天測定各組體溫和血象的變化[2]。 |
| 參考文獻 |
| 分子式 | C176H302N52O41S |
|---|---|
| 分子量 | 3834.67 |
| 儲存條件 | -20°C |
| 個人防護裝備 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危害碼 (歐洲) | Xi |
| 危險品運輸編碼 | NONH for all modes of transport |
| WGK德國 | 3.0 |
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Transcriptional analysis of a Photorhabdus sp. variant reveals transcriptional control of phenotypic variation and multifactorial pathogenicity in insects.
Appl. Environ. Microbiol. 77 , 1009-20, (2011) Photorhabdus luminescens lives in a mutualistic association with entomopathogenic nematodes and is pathogenic for insects. Variants of Photorhabdus frequently arise irreversibly and are studied becaus... |
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Comparative mode of action of novel hybrid peptide CS-1a and its rearranged amphipathic analogue CS-2a.
FEBS J. 279(20) , 3776-90, (2012) Cell selective, naturally occurring, host defence cationic peptides present a good template for the design of novel peptides with the aim of achieving a short length with improved antimicrobial potenc... |
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Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduce inflammation responses.
Colloids Surf. B Biointerfaces 110 , 225-35, (2013) Bacteria-related inflammation is a common postoperative complication in orthopedic implantation. In this study, cecropin B (CecB), a cationic peptide, was immobilized onto the surfaces of titanium sub... |
| H-Lys-Trp-Lys-Val-Phe-Lys-Lys-Ile-Glu-Lys-Met-Gly-Arg-Asn-Ile-Arg-Asn-Gly-Ile-Val-Lys-Ala-Gly-Pro-Ala-Ile-Ala-Val-Leu-Gly-Glu-Ala-Lys-Ala-Leu-NH2 |
| KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2 |
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